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Is it safe to drink cephalexin? Will there be side effects? What if I can’t give up alcohol?
Let’s address these important questions together today.
Whether you’re an occasional drinker or someone who’s worried about your alcohol use, this blog post will help you to let go of common misconceptions, understand the risks of drinking on cephalexin, and find out how you can get help for any form of unhealthy drinking.
Ready to have a more in-depth conversation about dependence or addiction? Call us on 0800 111 4108.

Cephalexin is an antibiotic that treats infections by killing bacteria. It’s a prescription-only medication that’s used to treat:
Drinking alcohol with cephalexin rarely causes serious complications, as the drug does not directly interact with alcohol.
However, alcohol can worsen certain symptoms, including indigestion and nausea, which means doctors recommend staying away from alcohol while you take this medication.
If you’ve been drinking alcohol while on cephalexin, there is nothing to worry about in terms of safety or efficacy.
Unlike metronidazole, which can cause severe reactions when combined with alcohol, cephalexin is generally safe to drink with alcohol, and the antibiotic will work just as well. The main concern is unpleasant symptoms.
Drinking frequently or heavily changes the situation. Whilst it’s still not extremely dangerous to drink a lot when taking cephalexin, harmful drinking behaviours can lead to:
All of these can worsen your physical state.
If it feels impossible for you to give up alcohol while you take cephalexin, you may be dealing with alcohol dependence or addiction. We’ll cover this later in the article, so please stick around for some clear guidance.
At Rehab4Alcoholism, we arrange referrals for alcoholism recovery, so we would be more than happy to talk to you about seeking help as soon as you’re ready.

Lots of people believe you must never drink when taking an antibiotic. It’s a generalisation that’s worth clearing up.
Sometimes it is dangerous to drink alcohol while you’re on a course of antibiotics, as the specific antibiotic doesn’t interact well with alcohol.
However, in some cases, as with cephalexin, direct interaction doesn’t occur.
A worsening of symptoms (such as dizziness, flushing and severe headaches) may be mistaken as a dangerous drug interaction, when in fact, it could simply be that alcohol slows the healing process, which worsens or prolongs symptoms.
Another common misconception is that alcohol completely eliminates the efficacy of cephalexin. Again, this isn’t true.
Whether you drink or not, cephalexin gets to work on killing bacteria. We have no reason to believe that alcohol stops cephalexin from working.
What alcohol does is make it much harder to have a smooth recovery. It can interrupt our sleep, reduce our energy, increase inflammation, add stress on the immune system, and worsen dehydration.
Of course, this is more likely to happen if we’re drinking excessively, as opposed to enjoying the occasional drink.
The side effects of cephalexin can be very similar to side effects caused by alcohol, from dizziness and nausea to stomach pains and diarrhoea.
Why does this matter?
It makes it much harder for patients to keep track of their symptoms, as they can’t be certain whether symptoms are caused by cephalexin or alcohol, or both.
It’s true that the NHS states “you can drink alcohol while taking cephalexin” (1).
However, some people interpret this as an encouragement to drink while taking this drug.
Please remember that this refers to the fact that cephalexin is not known to cause severe reactions in people who drink alcohol. It doesn’t mean it comes with zero risks.

There’s a significant difference between someone who drinks alcohol on one course of cephalexin and someone who drinks alcohol very regularly, regardless of the medication they’re taking.
It’s not a case of cephalexin suddenly becoming dangerous when it’s taken by a long-term alcohol user. Instead, the issue is that the long-term effects of alcoholism can seriously impact our immune system, making it challenging to recover well from any infection, including ones treated with cephalexin.
People who drink heavily or frequently may struggle with a weak immune system, which means the body can have difficulty:
They may also suffer with poor liver health, impaired judgement, and increased dehydration.
So, although drinking isn’t technically dangerous on cephalexin, certain drinking behaviours cause people to be particularly vulnerable when they develop an infection of any sort.
In a healthy adult who is taking cephalexin, it is highly unlikely for one alcoholic drink to cause a dangerous reaction.
Someone who is battling alcoholism should be much more wary.
Once you’re addicted to alcohol, continuing to drink is dangerous regardless of your circumstances, as it causes harm to your brain and body.
Drinking while taking cephalexin isn’t likely to worsen the situation drastically, but it may make you more poorly by interfering with your recovery, particularly if you have any other underlying health conditions, you’re elderly, or your infection and/or alcoholism is severe.
No, it is never a good idea to delay antibiotics so you can drink.
If you’ve been prescribed antibiotics, it’s for good reason, and your health should take priority. Delaying treatment could make your illness much worse and much harder to recover from, particularly as you’re adding alcohol to your system during this delay.
The idea of waiting until after the weekend to start a course of antibiotics may sound tempting, but it’s unsafe, and also a sign that you could be struggling to manage your relationship with alcohol (which we can help with).

There are certain antibiotics that should never be taken with alcohol. These are:
This applies to any type of alcoholic drink in any amount. Even a one-off glass of wine or pint of beer risks a dangerous reaction, as does a product containing small amounts of alcohol, such as some mouthwashes and cold medicines.
Symptoms may include:
It can also be very dangerous to drink alcohol while taking linezolid (Zyvox), due to the possibility of increased blood pressure, but this only applies to certain drinks, such as tap beer and red wine.
We’ve touched on the idea that struggling to give up alcohol indicates you may be battling a dependence or addiction. Let’s unpack this further, as it’s an issue that will only worsen the longer you ignore it.
Firstly, we want to acknowledge how powerful addiction is.
We know that when you’re not able to immediately give up alcohol, it’s not because you’re weak, it’s because alcoholism is a chronic brain disease that is incredibly tough, if not impossible, to cope with on your own.
If you’re unsure whether this applies to you, have a look at these signs of alcoholism, and consider whether any feel familiar:
You may relate to every single one of these, in which case, we’d strongly urge you to get in touch with Rehab4Alcoholism so our lovely advisors can talk you through what it would be like to get professional support (such as residential alcohol rehab).
Don’t assume you’re unaffected just because some of these symptoms don’t resonate with you. There are a wide range of alcoholism symptoms, so everyone experiences it differently.
What’s more, denial is a very common mindset for people with addiction, so you may be subconsciously downplaying your struggles.
Even early harmful alcohol use is worth addressing. Whilst addiction and dependence are more urgent scenarios, if you’ve got an unhealthy relationship with alcohol in any way, there are plenty of opportunities to learn healthy coping mechanisms and no longer feel as though you’re losing control.
We’ve tackled a specific question today, but what about the broader questions? Am I addicted to alcohol? How can I avoid dangerous detoxing, and where can I go to recover?
Those are questions we’d love to help you with during our 5-10 minute telephone assessment. Don’t worry, we won’t quiz you, we simply use the time to chat through your challenges and suggest helpful treatments (if you’re ready, we’ll even get started on referrals).
Don’t delay treatment any longer. Call us on 0800 111 4108 to connect with our wonderful team.
Below, we outline some frequently asked questions around this topic:
If you miss a dose of cephalexin, it’s not ideal, but it’s nothing to panic about.
Usually, the medication can still work effectively, as long as you take the next dose as soon as possible (after a certain amount of time this advice changes, so please speak to your GP if you’ve missed a dose).
Drinking while taking cephalexin makes it much more likely that you will forget a dose, even if you aren’t drinking heavily. This is yet another reason to avoid alcohol during this period.
There’s no fixed recommended time. However, it would be sensible to wait until you’ve finished the full course of cephalexin.
Cephalexin can interact unsafely with certain drugs, including metformin and probenecid (2). Always consult your GP before taking cephalexin, to avoid dangerous reactions.
[2] https://www.ncbi.nlm.nih.gov/books/NBK549780/